Which Cell Cycle Phase Do The Alkylating Agents Work On? (2023)

1. Types of Chemotherapy Drugs - SEER Training

  • Alkylating agents are generally considered to be cell cycle phase nonspecific, meaning that they kill the cell in various and multiple phases of the cell cycle.

  • Just like scalpels, lasers, and electric currents are used in surgery, the weapons used to fight cancer in chemotherapy are a host of anti-cancer drugs. How differently these drugs kill cancer cells, or prevent them from dividing, depends on their classification. Drugs in the same class kill cancer cells by the same mechanism: they all attack the same target within the cell.

2. The Influence of Cell Cycle Regulation on Chemotherapy - PMC - NCBI

  • Cell Cycle Regulation · Advances in the Combination...

  • Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair. The occurrence, development, and metastasis of ...

3. Alkylating Agents - Holland-Frei Cancer Medicine - NCBI Bookshelf

  • Types of Alkylating Agents · Cellular Resistance to...

  • The alkylating agents were the first nonhormonal drugs to be used effectively in the treatment of cancer, and the story behind the recognition of the antitumor effects of these compounds is a remarkable one. During World War I, toxic gases were used as military weapons. The most devastating of these gases was sulfur mustard (Figure 51-1). The compound was used as a weapon because of its vesicant effects, which produce skin irritation, blindness, and pulmonary damage. However, it was observed that troops and civilians who were exposed to sulfur mustard also developed bone marrow suppression and lymphoid aplasia. Because of these findings, sulfur mustard was evaluated as an antitumor agent.1 The closely related, but less toxic, nitrogen mustards of World War II vintage were selected for further study. Trials in patients with lymphoma demonstrated regression of tumors, with relief of symptoms.2–4 These results encouraged the search for nitrogen mustards that were more effective and less toxic and stimulated efforts to find other chemicals with antitumor activity.Figure 51-1Structure of sulfur mustard (bis[2-chloroethyl]sulfide).

4. Alkylating agents: Nursing Pharmacology - Osmosis

  • Alkylating agents are cell-cycle phase nonspecific, which means they work by ... First, they can attach an alkyl group to one of the DNA bases of cancer cells.

  • Alkylating agents: Nursing Pharmacology Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of Alkylating agents: Nursing Pharmacology.

5. Types of Chemotherapy - Chemocare

  • Alkylating Agents. Alkylating agents are most active in the resting phase of the cell. These types of drugs are cell-cycle non-specific.

  • Alkylating agents are most active in the resting phase of the cell.  These types of drugs are cell-cycle non-specific.  There are several types of alkylating agents used in chemotherapy treatments:

6. What's the difference? Chemotherapy drugs

  • Sep 1, 2021 · Alkylating agents work by introducing substances called alkyls into cancer cells. ... cell cycle called the “S-phase” of cell division. At that ...

  • Different types of chemotherapy drugs are designed to use different attack strategies.

7. Alkylating Agents for Breast Cancer - WebMD

  • Mar 25, 2022 · The agents are cell-cycle phase nonspecific. This means they can kill the cell in various and multiple phases of its life cycle. Alkylating ...

  • Alkylating agents are a type of cancer drug commonly used to treat breast cancer. Learn more about how they work.

8. Categories of Chemotherapeutic Agents - Mesothelioma

  • Alkylating chemotherapy drugs are effective during all phases of cell cycle. ... They are effective in the M phase of the cell cycle and work by inhibiting ...

  • Chemotherapy agents can be classified as cell-cycle specific agents and cell-cycle nonspecific agents.

9. Types of chemotherapy | University of Iowa Hospitals & Clinics

  • Oct 1, 2016 · Alkylating agents. This group of medicines works directly on DNA to keep the cell from reproducing itself. These drugs will kill cells in all ...

  • There are over 100 kinds of anti-cancer medicines. Doctors divide those 100+ drugs into various groups depending on how they affect chemical substances within the cancer cell, which activity or process in the cell the drug interferes, and what part of the cell cycle the drug affects.

10. Chemotherapy - CancerQuest

  • These drugs usually work by killing dividing cells. Since cancer cells have lost many of the regulatory functions present in normal cells, they will continue to ...

11. Types of Chemotherapy - Mesothelioma

  • Alkylating agents are the oldest and most commonly used class of chemotherapy drugs, and work by directly damaging DNA and preventing cancer cells from ...

  • Chemotherapy medicines for mesothelioma.

12. Chemotherapy Primer: Why? What? and How? | OncoLink

  • The cell cycle is divided into four phases: the G 1, S, G 2, and M phases. A chemotherapy agent may work in only one phase of the cycle (called cell-cycle ...

  • An introduction to chemotherapy, including history, various classes of chemo, how it works and how it is given.

13. Chemotherapy Drugs: Types, How They Work & Side Effects

  • Oct 20, 2022 · What they do: Alkylating agents damage cell DNA to prevent cancer cells from dividing. Nitrosoureas are a particular type of alkylating agent.

  • Chemotherapy drugs are medicine you receive to fight cancer. They work by killing fast-growing cells, like cancer cells.

14. Gemcitabine - RnCeus.com

  • Alkylating agents are generally considered to be cell cycle phase nonspecific, meaning that they kill the cell in multiple phases of the cell cycle.

  • Cytotoxic Chemotherapy

15. Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and ...

  • Jan 15, 2018 · Chemotherapeutics have diverse actions and cause different forms of DNA damage. Alkylating agents (e.g., temozolomide, dacarbazine ...

  • Abstract. Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-dependent kinases and checkpoint kinases induce cell-cycle arrest and apoptosis in neoplastic cells. Early phase I studies demonstrate targeted inhibitors can be administered safely in adult and pediatric cancer patients, but these agents generally show limited clinical benefits as single agents. In this review, we discuss biological mechanisms that support dual combination strategies of cell-cycle inhibition with chemotherapeutic agents that are anticipated to achieve rationally targeted therapies for cancer patients. The rationale for evaluating these combination strategies is that DNA damage renders tumors highly responsive to irreversible cell-cycle arrest therapy. This approach is predicted to generate less intensive therapies and to maximize the efficacy of individual agents against solid tumors and hematologic malignancies. Cancer Res; 78(2); 320–5. ©2018 AACR.

16. Alkylating Agents - A Clinical Pharmacological Overview

  • Sep 30, 2022 · The alkylating agents are not cell cycle-specific. But they are most active in the interphase- the phase in which the chromosomes can not ...

  • Alkylating agents are used in tandem with other anti-cancers drugs. Let’s review some considerations about these medications.

17. Chapter 54. Cancer Chemotherapy | Katzung & Trevor's Pharmacology

  • Tumor cells are usually most responsive to specific drugs (or drug groups) in the phases indicated. Cell cycle-nonspecific (CCNS) drugs act on tumor cells while ...

  • Read this chapter of Katzung & Trevor's Pharmacology: Examination & Board Review, 10e online now, exclusively on AccessPharmacy. AccessPharmacy is a subscription-based resource from McGraw Hill that features trusted pharmacy content from the best minds in the field.

18. Treatment Specifics | Central Care Cancer Center

  • As a class of drugs, these agents are not phase-specific (in other words, they work in all phases of the cell cycle). These drugs are active against chronic ...

  • Central Care Cancer Center provides expert cancer care in locations across the states of Kansas and Missouri.

19. Types of Chemotherapy Drugs

  • Alkylating agents: These types of drugs interfere with the way cells work and can kill cells in various phases of the cell cycle. · Antimetabolites: · Plant ...

  • Visit the Chemotherapy.com website and find important information.

20. List of Alkylating agents - Drugs.com

  • Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from ...

  • Compare alkylating agents. View important safety information, ratings, user reviews, popularity and more.

21. Chemotherapy Types - News-Medical.net

  • Chemotherapy Types · Normal cell cycle. All cells form through the division of their parent cells, a procedure called mitosis. · Alkylating agents. These agents ...

  • Cancer chemotherapy agents are classified according to their chemical nature and function. Some of the well known classes of cancer chemotherapy agents include alkylating agents, plant alkaloids, antimetabolites, anthracyclines, topoisomerase inhibitors and corticosteroids.

22. Understanding the Functions of Different Chemotherapy Agents

  • They are non-specific to the cell cycle and will kill cells in multiple phases of the cell cycle, including the rest phase for some. Although alkylating agents ...

  • Chemotherapy is one of many treatment options for patients with cancer. This form of therapy uses chemical agents (i.e., anti-cancer or cytotoxic drugs) that interact with cancer cells to eradicate or control the growth of cancer. Common alternative forms of treatment include surgery to remove all or a portion of a tumor as well as […]

23. Overview of Antineoplastic Agents - Pharmacology

  • Individual alkylating agents are generally cell cycle–nonspecific; however, they are most potent in late G1 and S phases. Agents can be classified according to ...

  • Learn about the veterinary topic of Overview of Antineoplastic Agents. Find specific details on this topic and related topics from the Merck Vet Manual.

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